Dating the origin of the ccr5

A 32-bp deletion in the CCR5 gene (), which results in a frameshift and truncation of the normal CCR5 protein, was identified in a few persons who had remained uninfected after exposure to CCR5-tropic HIV-1 viruses [7].

dating the origin of the ccr5-15

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Tropical Medicine & Surgery Gene mutation is a change in nucleotide sequence of DNA which results in an impaired or loss of functions of the associated gene.

However, some mutations, such as CCR5 gene mutation turns out to be beneficial.

HIV virus uses the gene product, CCR5, as a co-receptor along with CD4 receptor to enter the host’s cell.

Abdullahi Ibrahim Uba Center for Biotechnology Research Bayero University, Kano, P. B 3011 Nigeria/Department of Bioinformatics and Genetics Graduate School of Science and Engineering Kadir Has University, Istanbul, Turkey Tel: 90 212 533 65 32 E-mail: [email protected] Received Date: April 17, 2015 Accepted Date: July 31, 2015 Published Date: August 05, 2015 Citation: Uba AI, Usman SS, Musbahu MS, Abdullahi UA, Mustafa GM, et al.

(2015) Genetic Redundancy and Chemokines: CCR5 Δ32 HIVResistance Allele. doi:10.4172/2329-9088.1000191 Copyright: © 2015 Uba AIet al.Mutation can occur spontaneously or be induced by mutagenic agent.It is considered deleterious when it affects the phenotypic expression of the gene products.Prices in € represent the retail prices valid in Germany (unless otherwise indicated). Prices do not include postage and handling if applicable. Background: The mutant CCR5Δ32 allele confers resist- ance to HIV infection.Several hypotheses regarding its ori- gin and persistence in the human population have been proposed.We argue that closer collaboration between historians and scientists is needed to understand the selective pressures on genetic mutation, and the possible triggers for changes in genetic spatial frequencies over the past millennia.

Tags: , ,